Sex Chromosome Lab

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Genomics, Bioinformatics, and Sex Chromosome Evolution

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Sex Chromosome Lab

Male Mutation Bias

If most mutations result from errors during replication (during germline cell divisions), then differences in the rounds of germline cell divisions between males and females are expected to result in more mutations introduced from one parent or the other. In mammals, the male germline undergoes many more rounds of division than the female germline, and this is observed in a resulting "male mutation bias", where more mutations are introduced from the male versus the female germline. We study how this process occurs, and what its genomic impacts are.

Male Mutation Bias

If most mutations result from errors during replication (during germline cell divisions), then differences in the rounds of germline cell divisions between males and females are expected to result in more mutations introduced from one parent or the other. In mammals, the male germline undergoes many more rounds of division than the female germline, and this is observed in a resulting "male mutation bias", where more mutations are introduced from the male versus the female germline. We study how this process occurs, and what its genomic impacts are.

Male Mutation Bias Across Species

Male Mutation Bias Across Species

For a review of male mutation bias, with Kateryna Makova.
Read more here: Genome analyses substantiate male mutation bias in many species

Predictors of Male Mutation Bias

Predictors of Male Mutation Bias

We studied associations between variations in life history traits and molecular evolution, especially male mutation bias. We found that generation time is the strongest predictor of variation in male mutation bias across species. With Chris Venditti, Mark Pagel, and Kateryna Makova.
Read more here: Do variations in substitution rates and male mutation bias correlate with life-history traits? A study of 32 mammalian genomes